CDH1 and hepatocellular carcinoma: The pooled ORs were 0.73 (n = 6 studies, 95% CI: 0.54–1.00, Z = 1.95, P = 0.05) for1-year RFS, 0.70 (n = 6 studies, 95% CI: 0.52–0.95, Z = 2.32, P = 0.002) for 3-year RFS, 0.66 (n = 5 studies, 95% CI: 0.48–0.90, Z = 2.64, P = 0.008) for 5-year RFS., Taken together, the above results suggested that reduced E-cadherin expression exerted a significantly adverse effect on the prognosis of patients with HCC.