Additionally, we also assessed the association of reduced E-cadherin expression with tumor encapsulation and liver cirrhosis on the basis of seven studies [22], [23], [40], [42], [43], [50], [52] and ten studies [22], [23], [31], [34], [40], [42], [43], [49], [52], [53], respectively. This evidence concerns the gene CDH1 and cirrhosis of liver.