In a multivariate Cox proportional analysis adjusted for aspirin use, age (10-year increase), baseline eGFR, presence of proteinuria, previous CVD, diabetes, hypertension, hemoglobin level <10 g/dl, albumin level <3.5 g/dl, cholesterol level, and use of medications (RAAS blockers, statins, beta-blockers, CCBs, diuretics, warfarin, clopidogrel, and cilostazol), the risk of atherosclerotic CVD was significantly higher in aspirin users than in non-users in the unmatched cohort (HR, 2.577; 95% CI, 2.238–2.967; P<0.001; Table 2). This evidence concerns the gene ALB and diabetes mellitus.