This includes two of the NLRP3 SNPs, R260W and D303N (NOD2 R334 and D382), which are associated with cryopyrin-associated periodic syndromes (CAPS) gain of function diseases Muckle–Wells syndrome and Neonatal Onset Multisystem Inflammatory Disease [20]. The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.