By blocking neddylation of cullin, the best-characterized target of neddylation pathway thus far, MLN4924 has the ability to inactivate CRLs, leads to accumulation of its substrates, and thus eventually leads to suppression of several solid tumors and hematological malignancies both in vitro and in vivo [9, 21]. This evidence concerns the gene CACUL1 and hematologic disorder.