We examined the mutation status of neighboring genes around these risk loci (Table S2) in the Cancer Genome Project Data of Wellcome Trust Sanger Institute (http://www.sanger.ac.uk/genetics/CGP/cosmic/). CSMD3 in 8q23.3 is a large gene encoding a protein with CUB and sushi multiple domains and is associated with somatic mutations in lung cancer (7 mutated in 11 unique samples). This evidence concerns the gene CSMD3 and lung carcinoma.