We examined the mutation status of neighboring genes around these risk loci (Table S2) in the Cancer Genome Project Data of Wellcome Trust Sanger Institute (http://www.sanger.ac.uk/genetics/CGP/cosmic/). CSMD3 in 8q23.3 is a large gene encoding a protein with CUB and sushi multiple domains and is associated with somatic mutations in lung cancer (7 mutated in 11 unique samples). This evidence concerns the gene CSMD3 and cancer.