When the density of IL-6 positive cells was graded, it was shown that the increase of IL-6 positive cell density was started after induction for 14 weeks, became even higher after induction for 16 and 18 weeks, and reached the highest level after induction for 22 weeks (experimental terminal) in both transformed epithelium (Figure 4(c)) and tumor stroma (Figure 4(d)). This evidence concerns the gene IL6 and neoplasm.