The study revealed that the development of CAH in patients was associated with1.7- and 1.4-fold increases in the caspase-1 and caspase-3 activities (p< 0.05), respectively(Fig. 1,Fig. 2),which is indicative of intensification of apoptotic processes.Basic therapy resulted in changes inthe caspase activity toward normal values. The gene discussed is CASP1; the disease is congenital adrenal hyperplasia.