We have shown that pIX-modified RPANs (Ad5-EGFP-pIX-ER )carrying aCE A-RE on their surfaces three times more effectively penetrate intothe tumor cells lines A549 and Lim1215 via the CAR-independent pathway thanunmodified RPANs (Ad5-EGFP) and Ad5-EGFP-pIX-ER (pIX-modified RPANs, which donot have aCE A-RE on their surfaces). This evidence concerns the gene ACE and neoplasm.