The anti-apoptotic effect of PAK1 is ascribed to its ability to phosphorylate BAD, a pro-apoptotic protein that regulates the intrinsic cell death machinery, causing BAD to dissociate from BCL2 and associate with 14-3-3tau, cell survival is promoted as a result, thus empowering tumor cells the advantage to proliferate [39]. Here, PAK1 is linked to neoplasm.