TFF2 and irritable bowel syndrome: In addition, calcitonin gene-related peptide (CGRP), cholecystokinin, and neurotransmitters also play an important role in IBS visceral hypersensitivity, while central tachykinins (SP, NK1-3), NMDA, purinergic receptors, and other neurotransmitters also play important roles in the central mechanism of visceral hyperalgesia in IBS, and studies on the analgesic mechanisms of moxibustion via these neurotransmitters are yet to be carried out.