PROK1 and irritable bowel syndrome: Further studies on the central mechanism have found that at the Tianshu point (ST25) moxibustion can also reduce the expression of PK1 and PKR1 in the spinal cord of IBS rats [27], thereby inhibiting the transmission of pain signals as a result of IBS visceral hypersensitivity to the spinal cord dorsal horn neurons and higher areas in the central nervous system.