Combined with behavioral results, it has been found that the reduction of CRF and CRFR1 expression and increase in CRFR2 expression in the colon and the corresponding spinal segments, ultimately restoring the rhythmic balance of the HPA axis system [40], are closely associated with the central mechanism of the analgesic effect of moxibustion on visceral hyperalgesia in IBS rats. Here, CRHR1 is linked to irritable bowel syndrome.