They result from t(12; 16) or t(12; 22) chromosome translocation and have causative roles in development of MLS/RCLS [2–5]. FUS-DDIT3 and EWSR1-DDIT3 encode abnormal transcription factors that deregulate the expression of target genes [6–8]. The gene discussed is FUS; the disease is McLeod neuroacanthocytosis syndrome.