As shown in Fig. 6, TCEB2, HIF1A, TCEB1, CUL2, and RBX1 were involved in the renal cell carcinoma pathway, while TCEB2, HIF1A, TCEB1, and CUL2 had the highest degree in the PPI network. The gene discussed is CUL2; the disease is hereditary clear cell renal cell carcinoma.