Acetylsalicylic acid (ASA), an inhibitor of cyclooxygenase-1 (COX1) that prevents platelet thromboxane (Tx)-A2 formation [9, 10], used at low dose (100 mg/daily) in secondary CV prevention, is able to reduce clinical events in patients with coronary and peripheral artery disease and DM. Here, PTGS1 is linked to peripheral arterial disease.