In cases where early-onset cataract and glaucoma are co-inherited, suspicion is first directed toward genes encoding ocular transcription factors, notably PAX6, FOXE3, PITX3, and MAF that control development of anterior ocular structures including the cornea, iris, ciliary-body, iridocorneal angle drainage system (trabecular meshwork and Schlemms canal) and lens [32]–[34]. This evidence concerns the gene PITX3 and glaucoma.