Monoclonal antibodies such as cetuximab and panitumumab that target the epidermal growth factor receptor (EGFR), a human epidermal receptor (HER) family member, have proven to be efficacious in terms of response rate and progression-free survival in combination with standard cytotoxic chemotherapy in metastatic colorectal cancers (CRCs) [1]–[4]. Here, EGFR is linked to metastatic colorectal cancer.