Moreover, our study demonstrate that immunostaining for MYC, BCL2 and BCL6, with the optimal cut off of 90%, 70% and 20%, predict the presence of MYC breaks, IGH/BCL2 fusion and BCL6 breaks as detected by FISH in DLBCL with high specificity (>90%). This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.