In this study, therefore, we aimed to comprehensively assess the prognostic impact of protein expression patterns of MYC, BCL2, and BCL6 in concert with the chromosomal translocations targeting MYC, BCL2, and BCL6 in a Chinese cohort of 336 de novo DLBCL, NOS patients treated with CHOP or R-CHOP. The gene discussed is DDIT3; the disease is diffuse large B-cell lymphoma.