ZEB1 is one of the transcriptional inducer in the procedure of epithelial-mesenchymal transition (EMT) in cancer of epithelial origin, such as breast cancer, lung cancer, esophageal squamous cell carcinoma, gastric carcinoma, pancreatic cancer, cervical cancer, endometrial cancer and prostate cancer [23], [27]–[31]. Here, ZEB1 is linked to esophageal squamous cell carcinoma.