Besides ALS and FLTD-U, TDP-43 proteinaceous inclusions have been found as a secondary pathological feature in other diseases including Alzheimer's disease, Huntington's disease, Parkinson's disease, and hippocampal sclerosis, suggesting the broad impact of TDP-43 proteinopathy on the neurodegenerative disorders [8]–[10]. The gene discussed is TARDBP; the disease is Alzheimer disease.