TARDBP and frontotemporal dementia: Recently, accumulating evidences showed TDP-43 positive inclusions co-localized with Thioflavin S in the brain tissue of FTLD-TDP (Frontotemporal Lobar Degeneration with TDP-43 proteinopathy) and ALS cases, which provided the histological evidence in the amyloid property of TDP-43 [27], [28].