Therefore, the aim of our study was to investigate the effect of Leuprorelin acetate, a Gnrh-analog, on Gnrh and Gnrhr mRNA-expression, as well as on amyloid-β (Aβ) deposition in transgenic mice expressing amyloid-β precursor protein (AβPP) mutations with the Arctic and Swedish mutations (tgArcSwe), an established model of AD [26], [27]. Here, GNRH1 is linked to Alzheimer disease.