Similarly, ICR2 is methylated on the maternal allele resulting in the expression of CDKN1C and KCNQ1 but not KCNQ10T1, whereas ICR2 is not methylated on the paternal allele resulting in the expression of KCNQ10T1 but not CDKN1C and KCNQ1. The mechanism of IGF2 expression in adrenocortical tumors has been extensively analyzed, and it is now clear that this overexpression is due, at least in part, to paternal uniparental disomy (pUPD) at the 11p15 locus [14], [34]. The gene discussed is KCNQ1; the disease is adrenal cortex neoplasm.