Although experiments with SHSY5Y cells and mouse primary cortical neurons in culture and the 5XFAD mouse model certainly have limitations with respect to direct comparisons with the situation of neurons in the brain of AD patients, our results strongly suggest that RNS60 may be a novel tool to arrest Aβ-mediated neuronal apoptosis, glial activation and tau hyperphosphorylation, recognized pathological hallmarks seen in AD brains. Here, MAPT is linked to Alzheimer disease.