IL5 and Increased total eosinophil count: Compared to our study, where TLR agonists had no effect on TH2 cytokines or eosinophilia, Deuchs et al [44] has found that challenge with LPS and, in some cases poly (I:C), reduces levels of IL-4, IL-5 and eosinophilia in BALF when the TLR agonist is given 1 hr prior to each OVA challenge, between challenges or before all challenges.