C1GALT1 and cancer: It is not surprising that one O-glycosyltransferase could regulate various signaling pathways through different protein substrates [12], [20], [43], [44]._ENREF_24 In cancer cells, crosstalk between integrins and MET in regulating cell invasion, immunity, and development has been reported [45]–[48]._ENREF_42 Thus, it is reasonable to speculate that integrin β1 and MET signaling pathways cooperate to promote C1GALT1-mediated HCC malignancy, although detailed mechanisms remain to be further elucidated.