ANKRD1 and hypertrophic cardiomyopathy: A recent study revealed that hypertrophic cardiomyopathy (HCM) associated mutations in Ankrd1 (P52A, T123M, and I280V) have an increased binding ability of CARP to titin and myopalladin [9], while overexpression of either wildtype or HCM related mutant Ankrd1 (P52A or I280V) in cardiomyocytes reduced myocyte contractility [14].