Some studies indicated that CARP is a cardiac-restricted nuclear protein with a pivotal role in fetal development [23] or in failing and non-failing hearts of human [5], [24], but CARP was also detected in the cytoplasm rather than the nucleus of cardiomyocytes from HF patients [6], [25] or even in neonatal rat cardiomyocytes [9]. This evidence concerns the gene ANKRD1 and hydrops fetalis.