Similar to the genes for natriuretic peptides and β-myosin heavy chain (β-MHC), the gene for CARP (termed ankyrin repeat domain 1: Ankrd1) was also identified as a fetal gene, expression of which is augmented in both animals and humans with cardiac hypertrophy [3], [4] and heart failure (HF) [5], [6]. This evidence concerns the gene ANKRD1 and heart failure.