The authors conclude that autologous DC vaccination in advanced HCC patients is safe and well tolerated. Ex vivo treatment with CTLA-4 blocking antibodies of T-cell CD8+, isolated from patients affected by HCC, showed an expanded antigen-specific T-cell repertoire, alluding that ipilimumab may possess a therapeutic potential in treating hepatocarcinoma [99]. This evidence concerns the gene CD8A and hepatocellular carcinoma.