In cultured cells transfected with IL17RC or treated with VEGF , high levels of pIRS1, associating with type II Diabetes and causing insulin resistance (Liberman and Eldar-Finkelman 2005) (Figure 6) in that the body cells reduce their use of insulin (Kumar et al. 2005), and pTAU, associating with Alzheimer’s disease (Yang et al. 1999), have been detected (Figures 4 and 5). Here, INS is linked to early-onset autosomal dominant Alzheimer disease.