Since Wnt-signaling plays pathogenic roles in AMD in a mouse model and Wnt-3a induces vascular endothelial growth factor (VEGF) in ARPE (Zhou et al. 2010), protein levels of IL17RC and VEGF as well as mRNA levels of VEGF and Wnts in ARPE were examined. This evidence concerns the gene VEGFA and age-related macular degeneration.