Immune cells with high GSK3 activity may also increase risk of cardiovascular diseases (CVD) and cancer since the cells are suggested to be apoptotic (Jope & Johnson 2004; Watcharasit et al. 2002; Grimes and Jope 2001) or insensitive to PI3K/Akt stimuli (Figures 4 and6) or with impaired cell functions (24, Figures 4 and 6); hence, these cells may have low capabilities to eliminate LDL particles and cell debris from blood vessels and to destroy abnormal cells. Here, AKT1 is linked to cancer.