This research reveals relationships (Figure 6) among IL17RC, Wnt-signaling/VEGF and complement, which have been thought or treated as separate factors playing roles in AMD pathology in previous studies (Wei et al. 2012; Zhou et al. 2010; Zipfel et al. 2010); in addition, it is the first time that GSK3 is suggested to play pathological roles in AMD (Figure 6). The gene discussed is VEGFA; the disease is age-related macular degeneration.