Puerarin at 20 and 100 nM decreased the diabetes-induced elevation of TNF-α, IL-1β, and IL-6 (P < 0.001, Figure 5(a)) and NF-κB DNA binding activities (P < 0.01 and P < 0.001 at 20 nM and 100 nM, resp., Figure 5(b)). This evidence concerns the gene IL1B and diabetes mellitus.