TNF and cytomegalovirus infection: IL-6 drives reactivation of latent HCMV infection by transcriptional upregulation of IE genes [26]; HCMV IE and late proteins play important roles in immune evasion such as TNF-mediated death receptor signaling pathway, TNF-α release, IL-6 production [27, 28].We deduce that curcuminreduces HCMV IE and UL83 expression, which in turn decreases inflammatory factor secretion and recovers host cell cycle to normal status.