ZNF146 and autoimmune disease: IRF5 is known to regulate type I interferon response and has been causally linked to autoimmune disease through variants driving elevated expression of multiple unique IRF5 isoforms.58,59 rs2738459 was previously associated with LDL cholesterol levels in a population of European descent60 and was associated in our study with ZNF207, a relatively uncharacterized zinc finger protein.