SCN1A and epilepsy: This signal was centred on the voltage-gated sodium channel gene SCN1A, which is a known gene associated with some monogenic epilepsies.7, 28, 29 The most strongly associated variant in this interval was rs6732655 (p=8·71 × 10−10, OR 0·89, 95% CI 0·86–0·93; table 2, appendix), located in intron 16 of SCN1A. Seventy other variants in this region satisfied the threshold for genome-wide significance.