To this end, we used Tg6799 transgenic mice, which contain mutant human APP (695) with Swedish (K670N, M671L), Florida (I716V), and London (V717I) Familial Alzheimer’s Disease (FAD) mutations, as well as human PS1 with M146L and L286V FAD mutations [7]. This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.