To this end, we used Tg6799 transgenic mice, which contain mutant human APP (695) with Swedish (K670N, M671L), Florida (I716V), and London (V717I) Familial Alzheimer’s Disease (FAD) mutations, as well as human PS1 with M146L and L286V FAD mutations [7]. Here, PSEN1 is linked to Alzheimer disease.