The incidence of PPIX–PDD positivity did not increase with increase in the total PSA levels (p = 0.25) and tumor stage (p = 0.87).Furthermore, the diagnostic accuracy of PPIX–PDD in the males with positive biopsies was 15/24 (62.5%) for Gleason score (GS) 6, 26/34 (76.4%) for GS 7, and 19/23 (82.6%) for GS 8–10.The incidence of PPIX–PDD positivity increased with increasing GS, but the increase was not significant (p = 0.11) (Table 3). Here, KLK3 is linked to neoplasm.