Decreased SIRT6 protein levels and deletion of the SIRT6 gene occur in human colon, pancreatic and hepatocellular carcinomas, and in cancer cell lines, consistent with a tumor suppressor role for human SIRT6 (Lin et al., 2013; Sebastián et al., 2012; Zhang and Qin, 2013). The gene discussed is SIRT6; the disease is hepatocellular carcinoma.