Increased expression of HIF-1α and HIF-2α has been detected in many different cancer types as well as in tumor-associated stromal cells, and, in both cases, high HIF levels are associated with a poor clinical outcome (Bonuccelli et al., 2010; Keith et al., 2012; Pavlides et al., 2010; Semenza, 2010). The gene discussed is EPAS1; the disease is neoplasm.