However, the tumorigenic effects of ΔNp63 may also be mediated by promoting the transactivation of target genes such as those encoding Lsh, which is a chromatin remodeler, involved in tumorigenesis and stem cell proliferation as well as genes encoding interleukin (IL)- 6 and (IL)-8 that are involved in tumor angiogenesis associated with neuroblastomas and osteosarcomas [9, 10]. The gene discussed is CXCL8; the disease is neoplasm.