The additional association of eSNPs within a coexpression module with the disease of interest provides further statistical support that the coexpression module is involved in the disease, as the module is then not only enriched for eSNPs (e.g. SNPs associated with CD4+ gene expression), but more specifically, enriched for disease-associated eSNPs (e.g. SNPs associated with both CD4+ gene expression and allergic rhinitis). The gene discussed is CD4; the disease is allergic rhinitis.