Indeed, when extending these analyses to other hypermutators, that is, UV-light-induced melanoma (Pleasance et al., 2010), tobacco smoke-induced small cell lung adenocarcinoma (SCLC) (Pleasance et al., 2010), as well as breast tumors deficient for BRCA1 (Nik-Zainal et al., 2012) or EM tumors proficient for MMR, patterns were clearly dissimilar from the matched germ-line (Figure 2A). The gene discussed is BRCA1; the disease is small cell lung carcinoma.