Inverse correlation with E-cadherin [130]; markedly high expression (78% of tested tumors, n = 59) of Snail; Snail-positive in older age group than Snail-negative (mean 58.9 vs. 49.8, n = 59) [138]; Snail expressed in all tested CRC cell lines (Western blot); expression increased migration and invasiveness; decreased E-cadherin; led to CSC-like phenotype and spindle morphology [139]. This evidence concerns the gene CDH1 and colorectal carcinoma.