In addition, TNF-α, interferon-gamma (IFN-γ), early growth response gene-1 (EGR-1), hypoxia-inducible factor 1 alpha (HIF-1α), and transforming growth factor-beta (TGF-β) upregulate flTF in cancer cells and endothelial cells [6],[49]-[51]. This evidence concerns the gene IFNG and cancer.