In addition to the pore-forming function, VDAC1 is involved in various interactions and cross-talk with other cellular proteins like hexokinase [8], tubulin [9], the Ca2+ gating into mitochondria [10] and the Bcl-2 family members [11] that can impact on the activity of the pore itself and vice versa, testimony to the involvement of VDAC to crucial cell fates [12] like in pathways leading to apoptosis [13]–[15], cancer [16], [17] and degeneration [18]. This evidence concerns the gene VDAC1 and cancer.