There was a significant statistical association of the promoter hypermethylation of the ABCG1 gene with CHD risk (OR = 22.859; 95% CI, 8.989–58.135; p<0.001 and OR = 19.966; 95% CI, 7.319–54.468; P*<0.001; P*: adjusted for age, gender, smoking, lipid level, hypertension, and diabetes). The gene discussed is ABCG1; the disease is hypertensive disorder.