In conclusion, the results of the present study suggest plasma and urinary α-klotho may be the early markers for predicting renal injury in patients with type 2 diabetes and we need to do long-term prospective study in order to elucidate the role of α-klotho in the pathophysiological mechanisms of the development and progression of albuminuria in type 2 diabetes. The gene discussed is KL; the disease is type 2 diabetes mellitus.