The mean counts of Ki-67-positive nuclei in normal duct and during IPMN progression (adenoma, borderline atypia, CIS, and invasive carcinoma) were 1.29%, 2.63%, 11.04%, 22.18%, and 23.23% respectively. Here, MKI67 is linked to pancreatic intraductal papillary-mucinous neoplasm.