Immunohistochemical staining for EZH2 and p27KIP1 was performed on serial sections to determine whether the increased EZH2 expression, which acts as an epigenetic gene silencer, was associated with the downregulated p27Kip1 expression during IPMN progression (Figure 4d). This evidence concerns the gene EZH2 and pancreatic intraductal papillary-mucinous neoplasm.