Although the BMI-1 expression in malignant IPMNs was significantly higher than that in non-malignant IPMNs (Figure 5a), similar to EZH2 expression, the correlation between BMI-1 and Ki-67 expression in IPMN lesions (Figure 5b, p<0.0001, R2 = 0.1587) revealed a weaker positive correlation compared to that between in EZH2 and Ki-67 expression (p<0.0001, R2 = 0.5226). This evidence concerns the gene EZH2 and pancreatic intraductal papillary-mucinous neoplasm.