To ascertain the relationship between EZH2 and p27Kip1, mRNA levels were examined in elective 20 IPMN (borderline IPMN in 11, CIS in 5, invasive carcinoma in 4) lesions and 4 pancreatic normal ducts. This evidence concerns the gene CDKN1B and pancreatic intraductal papillary-mucinous neoplasm.