Especially, a detailed view of the genomic changes in a large TCGA GBM cohort containing 206 patient samples confirmed previously reported GBM-associated mutations such genes as EGFR, PDGFR, MET, PTEN, TP53, RB1, PIK3R1, NF1, and ERBB2 [10]. The gene discussed is RB1; the disease is glioblastoma.