Among the genes affected by the very rare CNVs are FOXO3, which recently has been shown to be differentially methylated and differentially expressed in a comparison between normal endometrial and endometriotic stromal cells [24], and TFF3, which is an estrogen-responsive gene shown to be up-regulated in endometrioid adenocarcinomas [25]. Here, FOXO3 is linked to endometrioid adenocarcinoma.