In agreement with higher tumor burden by BTK-KD MM cells in vivo was the overexpression of MM-associated markers such as SDC1 and CLK2 and heparanase target gene, PLXNC1. 27,28 Additional upregulated genes, such as ADA, negatively regulate leukocyte migration (Figure 5c). The gene discussed is PLXNC1; the disease is Miyoshi myopathy.