BTK and Miyoshi myopathy: They also showed that ibrutinib treatment inhibits the clonogenic potential of stem-like cells sorted from MM cell lines or MM patients, and it inhibits growth of INA6 cells in the SCID-hu model.17 Further, relatively high concentrations of BTK inhibitors have been shown to enhance the cytotoxic effects of bortezomib and lenalidomide on MM cell lines in vitro.