SPAG6 and neoplasm: Among the genes most upregulated in BTK-KD cells were several factors associated with lymphoid malignancies, including BCL11A, SYK and TIAM1, and tumor- and testis-related antigens associated with proliferation, such as RAB31, MAGEA2 and SPAG6. Several genes related to PI3K/AKT/mammalian target of rapamycin (mTOR) signaling were upregulated such as LGALS1, EIF4E2 and SEMA4D suggesting increased cell activity associated with proliferation.