COL24A1 and Miyoshi myopathy: COL24A1 has antiangiogenic function in MM and its downregulation suggests that BTK-KD MM tumors are well equipped with angiogenic vessels for enhanced growth.42 These observations suggest that adhesive signals from MM cells could permit BM microenvironment to dictate tumor growth partly through regulation of constitutively active RAS/PI3K/mTOR pathway.