AKT1 and Miyoshi myopathy: Several of the most downregulated genes (for example, ST3GAL6, CT45, LPXN, RHOU) have been implicated with cellular adhesion and motility, whereas many upregulated genes are associated with activation of PI3K/AKT/mTOR signaling (for example, LGALS1, EIF4E2, MAPKAP1, SEMA4D) and cell proliferation (for example, BCL11A, RAB31).37, 38, 39 In BTK-KD INA6 cells, increased protein expression and phosphorylation of mTOR suggests that the loss of BTK and subsequent adhesion to stroma may increase proliferative potential of MM cells.