BTK and Miyoshi myopathy: 32 In contrast, we recently reported that short-term in vitro growth of INA6 cells was not profoundly affected by BTK inhibitor LFM-A13 or from stable knockdown of BTK, whereas another study using BTK inhibitor CC-292 showed moderate inhibitory effects on INA6 cells but not on other MM cell lines.16,19 In the present study, clonogenicity of BTK-KD cells was lower than control cells, but their overall growth in coculture with supportive osteoclasts was enhanced and their growth and proliferation in the SCID-rab model were higher than control cells.