Our group of sporadic EOCRC, characterized by a CIN-like profile, CIMP-, and beta catenin activation can be compared with the CIN+ subtype of Marisa's classification with an up-regulation of the Wnt pathway, but it also has a specific up-regulation of the TNF-R1 and adhesion/motility pathways. Here, TNFRSF1A is linked to cervical squamous intraepithelial neoplasia.