Since NAC, as an antioxidant, inhibits the transcription factors activity of NF-kB and AP-1, it influences the activity of the signaling pathway of MAP-kinase and results in a reduction in the oxidative stress (11-13); therefore, it is possible that NAC can decrease elevated oxidative stress in PCOS patients taking MTF. Here, NFKB1 is linked to polycystic ovary syndrome.