Specifically, we found that the combination of TSHI + LPS leads to neonatal encephalomalacia and ventriculomegaly, acute chronic microgliosis and astrocytosis in white matter, and decreased myelin basic protein (MBP) expression, neurofilament (NF) ratio and motor deficits in juvenile postnatal day 28 (P28) rats. This evidence concerns the gene MBP and encephalomalacia.