PDIA3 and Alzheimer disease: Grp58 was significantly overexpressed in AD (214.6 ± 78.4), compared with non-tumor epithelium (72 ± 70.1; P = 0.005), while β-catenin was significantly downregulated in AD (Q of AD and non-tumor epithelium were 161.7 ± 69.8 and 242 ± 53.1, respectively; P = 0.035; Figure 4C).