In vivo binding sites of the TF, nucleosome positions and transcriptome profiles of both the metastatic and induced non-metastatic state in lung cancer cells were then determined (see Scheme S1 in Supplementary Information for a summary of the overall design) and using these, the correlation between target site occupancy, nucleosome reorganization and their combined effect on the transcriptome was examined. This evidence concerns the gene TF and lung cancer.